The need to check that there aren’t any genetic problems comes up often enough. Performing such a test may cause an early termination of the pregnancy. If something unfortunate does happen, it’s risky for the mother and can cause serious psychological trauma for relatives.
The development of IVF technology has allowed the unique opportunity to understand the genetic health of a child even before the embryo is transferred into future mother’s uterus. This method is called PGD (preimplantation genetic diagnosis). The technical details behind PGD are interesting, but typically understood by a small group of experts. Without diving into the science behind PGD, the method can be described as follows: a cell is taken from an embryo obtained during IVF and then to a specialized laboratory for genetic testing to find abnormalities. The procedure does not hurt the embryo and has no impact on its further development.
Generally, doctors recommend PGD in the following cases:
In any case, at our GMS IVF Family Planning Center, we strongly recommend PGD «by default» since most of our in vitro fertilization programs already include basic genetic abnormality exams for embryos. There are some key reasons to choose this procedure.
Unfortunately, fertility problems that involve genetic abnormalities are quite common. Due to this fact, patients are forced to resort to IVF to conceive must pay special attention to genetics.
Let’s be honest: how often are we completely sure that we know everything about our genetics or even our family genetics? Beyond that, what about the «genetic health» of our partner? Basically, deciding to undergo IVF is an indication that a child is something you’ve wanted for a long time. This is why we strive to exclude unnecessary risks for this child while saving valuable time from being wasted on useless attempts with an unfortunate result. It’s better to spend the time on looking for a way to get what you’ve been longing for.
That being said, as much as we recommend this critical service for IVF, we also want this procedure to be accessible to all patients. We don’t make money from the medical procedures involving collecting cells for embryonic screening. The price of PGD is as low as possible for our patients.
For patients with different financial situations, we have two different ways to complete the preimplantation genetic diagnosis available: comparative genomic hybridization (aCGH) method and the NGS method. Without getting technical, the second method can be described as more precise because each nucleotide is examined, but this also makes the price higher. Basic PGD, included in the Basic IVF program at the GMS IVF Clinic, is performed by doing a trophectoderm biopsy on the 5th day of embryonic growth and examines 46 chromosomes (22 couples of autosomes+ heterochromosomes).
As previously mentioned, PGD is only available for those who plan to undergo in vitro fertilization. We recommend Prenetics in the following cases: if other methods of assisted reproduction (for example, artificial or intrauterine insemination) have been used, if PGD was not included in your IVF program for any reason, and, of course, if insemination was successful. Compared to traditional genetic tests for embryos, the most important characteristics of this test are that:
The Prenetics test only requires 20 ml of the future mother’s blood like most biochemical analyses. After that, experts examine the DNA in a lab and learn the chance of fetal chromosomal abnormalities from the results. This test specifically examines the DNA of the baby which means it’s a direct diagnostic test and not a «Double Marker Test» (biochemical blood test and ultrasound). This test identifies chromosomal abnormalities with a high level of accuracy.
At the GMS IVF Clinic, we strive to work to the best of our ability and make PGD accessible to all of our patients. By having your genetic diagnosis done at our GMS IVF Clinic, you receive:
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